Researchers Scour Century-Old Tumor Samples for Clues on Rising Colorectal Cancer Rates Among Young Adults
A puzzling trend is unfolding among younger adults: colorectal cancer rates are surging at an alarming rate. Despite overall declining rates of the disease, those under 55 are now seeing a 1% to 2% increase each year since the mid-1990s. In fact, nearly one in five cases are diagnosed in individuals under 55 – making it the leading cause of cancer death among men aged 50 and younger, and second among women in the same age bracket.
The reasons behind this disturbing trend remain a mystery. Researchers point to potential culprits like increased ultra-processed food consumption, sedentary lifestyles, and rising obesity rates. However, the exact link between these factors and colorectal cancer remains unclear.
Enter an unlikely source of answers: the basement archives at St Mark's National Bowel Hospital in London. The hospital boasts an astonishing 10,000+ tumor tissue samples and gut bacteria preserved from every patient treated for colorectal cancer – a veritable "treasure trove" of data waiting to be unraveled. By analyzing these century-old samples using molecular DNA analysis, scientists hope to uncover the patterns behind shifting trends in younger adult cases.
Intriguingly, researchers have identified a type of gut bacteria (E. coli) now present in people's bowels but not previously. This microbe may emit toxins that stimulate the growth of cancerous cells – a hypothesis being tested by experts at the Institute of Cancer Research. By scouring these ancient tumor samples, scientists are determined to shed light on this enigmatic phenomenon and uncover the underlying causes driving the rising rates of colorectal cancer among younger adults.
A puzzling trend is unfolding among younger adults: colorectal cancer rates are surging at an alarming rate. Despite overall declining rates of the disease, those under 55 are now seeing a 1% to 2% increase each year since the mid-1990s. In fact, nearly one in five cases are diagnosed in individuals under 55 – making it the leading cause of cancer death among men aged 50 and younger, and second among women in the same age bracket.
The reasons behind this disturbing trend remain a mystery. Researchers point to potential culprits like increased ultra-processed food consumption, sedentary lifestyles, and rising obesity rates. However, the exact link between these factors and colorectal cancer remains unclear.
Enter an unlikely source of answers: the basement archives at St Mark's National Bowel Hospital in London. The hospital boasts an astonishing 10,000+ tumor tissue samples and gut bacteria preserved from every patient treated for colorectal cancer – a veritable "treasure trove" of data waiting to be unraveled. By analyzing these century-old samples using molecular DNA analysis, scientists hope to uncover the patterns behind shifting trends in younger adult cases.
Intriguingly, researchers have identified a type of gut bacteria (E. coli) now present in people's bowels but not previously. This microbe may emit toxins that stimulate the growth of cancerous cells – a hypothesis being tested by experts at the Institute of Cancer Research. By scouring these ancient tumor samples, scientists are determined to shed light on this enigmatic phenomenon and uncover the underlying causes driving the rising rates of colorectal cancer among younger adults.