Cholera Outbreaks Surge in Africa, Yet a Cure Remains Elusive
A dire situation has unfolded worldwide as cholera cases continue to rise rapidly across 32 countries. The resurgence of this ancient disease has resulted in over 6,800 deaths reported so far this year, exceeding last year's toll of approximately 6,000 fatalities.
Cholera's prevalence is largely tied to conflict and inequality, with the World Health Organization (WHO) describing it as a "definitive disease of deprivation." The Global Task Force on Cholera Control, led by the WHO, has been working tirelessly to combat outbreaks through access to essential supplies, detection, prevention, and treatment.
However, vaccine development and distribution remain severely hampered. Only one manufacturer, EUBiologics, is capable of producing cholera vaccines at the required scale, resulting in a lack of investment from vaccine developers who see limited market opportunities. A single manufacturer's capacity, coupled with the limited availability of effective vaccines, underscores the urgent need for expanded production.
In an attempt to address this shortage, the WHO and other partners have established a global cholera vaccine stockpile. Since its inception, the stockpile has distributed nearly 255 million doses to 34 countries. Notably, almost 75% of these doses were dispensed since 2021 in response to the current resurgence.
Vaccines from the stockpile are now being utilized to control outbreaks rather than prevent them. Given the increasing frequency and severity of cholera outbreaks, it is imperative that production keeps pace with demand. The stockpile's replenishment schedule is insufficient to meet this requirement.
To mitigate the crisis, a continental cholera emergency response plan was launched in August by the WHO and the Africa Centres for Disease Control and Prevention. Moreover, Zambia has signed an agreement with China's Jijia Medical Technology Company to establish a local vaccine-production facility.
However, experts stress that safe drinking water and sanitation are essential to preventing cholera outbreaks. The disease can be eradicated if poverty, inequality, conflict, and displacement are addressed. Consequently, halting the spread of cholera is as much a political challenge as it is scientific or medical.
A dire situation has unfolded worldwide as cholera cases continue to rise rapidly across 32 countries. The resurgence of this ancient disease has resulted in over 6,800 deaths reported so far this year, exceeding last year's toll of approximately 6,000 fatalities.
Cholera's prevalence is largely tied to conflict and inequality, with the World Health Organization (WHO) describing it as a "definitive disease of deprivation." The Global Task Force on Cholera Control, led by the WHO, has been working tirelessly to combat outbreaks through access to essential supplies, detection, prevention, and treatment.
However, vaccine development and distribution remain severely hampered. Only one manufacturer, EUBiologics, is capable of producing cholera vaccines at the required scale, resulting in a lack of investment from vaccine developers who see limited market opportunities. A single manufacturer's capacity, coupled with the limited availability of effective vaccines, underscores the urgent need for expanded production.
In an attempt to address this shortage, the WHO and other partners have established a global cholera vaccine stockpile. Since its inception, the stockpile has distributed nearly 255 million doses to 34 countries. Notably, almost 75% of these doses were dispensed since 2021 in response to the current resurgence.
Vaccines from the stockpile are now being utilized to control outbreaks rather than prevent them. Given the increasing frequency and severity of cholera outbreaks, it is imperative that production keeps pace with demand. The stockpile's replenishment schedule is insufficient to meet this requirement.
To mitigate the crisis, a continental cholera emergency response plan was launched in August by the WHO and the Africa Centres for Disease Control and Prevention. Moreover, Zambia has signed an agreement with China's Jijia Medical Technology Company to establish a local vaccine-production facility.
However, experts stress that safe drinking water and sanitation are essential to preventing cholera outbreaks. The disease can be eradicated if poverty, inequality, conflict, and displacement are addressed. Consequently, halting the spread of cholera is as much a political challenge as it is scientific or medical.