Researchers at the University of Texas at Austin and the University of Porto in Portugal have made a breakthrough in the fight against cancer with a new light-based therapy that kills tumor cells without damaging healthy ones. The treatment uses tiny particles called nanoflakes, which are infused into cancer cells and then targeted with near-infrared (NIR) light to produce heat that destroys the cancer.
The team developed materials capable of converting NIR efficiently and safely into this targeted heat, using tin oxide (SnOx) nanoflakes. These nanoflakes have a thickness of less than 20 nanometers and are designed to accumulate specifically in tumor tissues. When exposed to light at a wavelength that gives these materials the energy they need to produce cancer-killing heat, the SnOx nanoflakes turn this non-invasive procedure into a targeted treatment.
The researchers tested their new material on skin cancer cells and found that it killed up to 92% of them within just 30 minutes. The treatment also showed promise against colorectal cancer, killing 50% of the cancer cells with the same exposure time.
One of the lead authors, Jean Anne Incorvia, said that their goal was to create a treatment that is both effective and safe and accessible for patients everywhere. With the combination of LED light and SnOx nanoflakes, they have developed a method to precisely target cancer cells while leaving healthy ones untouched.
Further studies are still needed, but this breakthrough could potentially make photothermal therapy a viable option for cancer patients. According to researchers Artur Pinto from the University of Porto's School of Engineering, their technology could one day be used in a portable device placed on the skin after surgery to destroy any remaining cancer cells, thus reducing the risk of recurrence.
The development of this new treatment is significant because it offers a safer alternative to traditional chemotherapy and radiotherapy. Unlike these treatments, which can harm both cancer cells and healthy ones, the SnOx nanoflakes-based therapy seems to be highly selective in its targeting of cancer cells.
The team developed materials capable of converting NIR efficiently and safely into this targeted heat, using tin oxide (SnOx) nanoflakes. These nanoflakes have a thickness of less than 20 nanometers and are designed to accumulate specifically in tumor tissues. When exposed to light at a wavelength that gives these materials the energy they need to produce cancer-killing heat, the SnOx nanoflakes turn this non-invasive procedure into a targeted treatment.
The researchers tested their new material on skin cancer cells and found that it killed up to 92% of them within just 30 minutes. The treatment also showed promise against colorectal cancer, killing 50% of the cancer cells with the same exposure time.
One of the lead authors, Jean Anne Incorvia, said that their goal was to create a treatment that is both effective and safe and accessible for patients everywhere. With the combination of LED light and SnOx nanoflakes, they have developed a method to precisely target cancer cells while leaving healthy ones untouched.
Further studies are still needed, but this breakthrough could potentially make photothermal therapy a viable option for cancer patients. According to researchers Artur Pinto from the University of Porto's School of Engineering, their technology could one day be used in a portable device placed on the skin after surgery to destroy any remaining cancer cells, thus reducing the risk of recurrence.
The development of this new treatment is significant because it offers a safer alternative to traditional chemotherapy and radiotherapy. Unlike these treatments, which can harm both cancer cells and healthy ones, the SnOx nanoflakes-based therapy seems to be highly selective in its targeting of cancer cells.